Locational effects on oral microbiota among long-term care patients. Issue 1 (31st December 2022)

• Record Type: Journal Article
• Authors: Tsai, Fa-Tzu; Wang, Ding-Han; Yang, Cheng-Chieh; Lin, Yu-Cheng; Huang, Lin-Jack; Tsai, Wei-Yu; Li, Chang-Wei; Hsu, Wun-Eng; Tu, Hsi-Feng; Hsu, Ming-Lun
• Is Part Of: Journal of oral microbiology. Volume 14:Issue 1(2022)
• Publication Date: 2022-12-31
• Subjects: Oral microbiota -- next-generation sequencing (NGS) -- long-term care patients -- home care -- outpatient department (OPD); Mouth -- Microbiology -- Periodicals; Medical microbiology -- Periodicals; Mouth Diseases -- microbiology; Mouth -- microbiology; Medical microbiology; Mouth -- Microbiology; Oral Pathology; Microbiology; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; Electronic journals; 616.31
• DOI: 10.1080/20002297.2022.2033003
• Languages: English
• ISSNs: 2000-2297

Abstract

ABSTRACT: Background: Dysbiosis of oral microbiota is the cause of many diseases related to oral and general health. However, few Asia-based studies have evaluated the role of oral microbiota in patients receiving long-term care. Thus, new indications are needed for early prevention and risk management based on information derived from the oral microbiota. Methods: We used next-generation sequencing (NGS) to identify the oral bacterial composition and abundance in patients receiving long-term care: 20 from the outpatient department (OPD) and 20 home-care patients. Their microbial compositions, taxonomy, and alpha/beta diversity were characterized. Results: Microbiota from the two groups showed different diversity and homogeneity, as well as distinct bacterial species. A more diverse and stable microbial population was observed among OPD patients. Our findings indicated that home-care patients had a higher risk of oral diseases due to the existence of dominant species and a less stable microbial community. Conclusion: This work was the first in Taiwan to use NGS to investigate the oral microbiota of long-term care patients. Our study demonstrated the potential use of dominant bacterial species as biomarkers for the risk management of posttreatment complications.