RNASEL 1623A>C variant is associated with the risk of prostate cancer in African descendants. Issue 7 (20th February 2019)

• Record Type: Journal Article
• Authors: Wang, Jian; Yuan, Wei; Yue, Chuang; Dai, Feng; Gao, Shenglin; Mi, Yuanyuan; Bai, Yu; Zhang, Lifeng; Zuo, Li; Wu, Xingyu; Zhang, Wei
• Is Part Of: Journal of cellular biochemistry. Volume 120:Issue 7(2019)
• Page Start: 11955
• Page End: 11964
• Publication Date: 2019-02-20
• Subjects: enzyme‐linked immunosorbent assay -- genetic variation -- polymorphism -- prostate cancer -- ribonuclease L; Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.28479
• Languages: English
• ISSNs: 0730-2312

Abstract

Abstract: Association between ribonuclease L (RNASEL) gene 1623A>C polymorphism and prostate cancer (PCa) susceptibility has been assessed in large quantities of studies but with controversial conclusions. We undertook a pooled analysis containing 7397 PCa cases and 6088 control subjects to assess the correlation between RNASEL 1623A>C polymorphism and PCa risk. Moreover, we used enzyme‐linked immunosorbent assay to test the serum RNASEL expression among patients enrolled in our centers and in‐silico tools were also utilized. The overall results of our analysis indicated a positive relationship between 1623A>C variant and PCa risk (allelic contrast, odds ratio [OR] = 1.07; 95% confidence interval [CI] = 1.02‐1.12; P heterogeneity = 0.575; CC vs AA, OR = 1.14; 95% CI = 1.03‐1.26; P heterogeneity = 0.217; CC + CA vs AA, OR = 1.10; 95% CI = 1.01‐1.19; P heterogeneity = 0.303; and CC vs CA + AA, OR = 1.08; 95% CI = 1.00‐1.17; P heterogeneity = 0.298). In ethnicity subgroup analysis, similar results were especially indicated in African descendants. In addition, serum RNASEL levels in PCa cases with CC + CA genotypes were higher than those with AA genotypes. Our present study showed evidence that RNASEL 1623A>C polymorphism is related to PCa risk, especially in African descendants. Abstract : We used enzyme‐linked immunosorbent assay (ELISA), pooled analysis and in‐silico tools to evaluate RNASEL variant in prostate cancer (PCa) risk. Our results showed evidence that RNASEL 1623A>C polymorphism is related to PCa risk, especially in African descendants.