Cover Feature: Evaluation of 3‐ and 4‐Phenoxybenzamides as Selective Inhibitors of the Mono‐ADP‐Ribosyltransferase PARP10 (ChemistryOpen 10/2021). Issue 10 (29th September 2021)

• Record Type: Journal Article
• Authors: Korn, Patricia; Classen, Arno; Murthy, Sudarshan; Guareschi, Riccardo; Maksimainen, Mirko M.; Lippok, Barbara E.; Galera‐Prat, Albert; Sowa, Sven T.; Voigt, Catharina; Rossetti, Giulia; Lehtiö, Lari; Bolm, Carsten; Lüscher, Bernhard
• Is Part Of: ChemistryOpen. Volume 10:Issue 10(2021)
• Page Start: 929
• Page End: 929
• Publication Date: 2021-09-29
• Subjects: ADP-ribosylation -- cell proliferation -- compound screening -- DNA repair -- molecular modeling; Chemistry -- Periodicals; 540; 540.5
• DOI: 10.1002/open.202100215
• Languages: English
• ISSNs: 2191-1363

Abstract

Abstract : The Cover Feature shows the functions of protein coding PARP10 gene in multiple processes, including DNA repair, signaling and innate immunity. Moreover, the PARP10 gene is amplified in certain solid tumors. The exogenous expression of PARP10 can induce apoptosis, an assay that has been used to screen for small molecule PARP10 inhibitors. More information can be found in the Full Paper by Patricia Korn et al .