Emerging roles of microRNAs in regulating the mTOR signaling pathway during tumorigenesis. Issue 7 (5th February 2019)

• Record Type: Journal Article
• Authors: Javid, Hossein; Soltani, Arash; Mohammadi, Fariba; Hashemy, Seyed Isaac
• Is Part Of: Journal of cellular biochemistry. Volume 120:Issue 7(2019)
• Page Start: 10874
• Page End: 10883
• Publication Date: 2019-02-05
• Subjects: autophagy -- cancer -- mammalian target of rapamycin -- microRNAs -- phosphoinositide 3‐kinase; Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.28401
• Languages: English
• ISSNs: 0730-2312

Abstract

Abstract: The mammalian target of rapamycin (mTOR) is a large Ser/Thr protein kinase that belongs to the phosphoinositide 3‐kinase (PI3K) family and mediates various physiological and pathological processes, especially cell proliferation, protein synthesis, autophagy, and cancer development. The mTOR expression is transient and tightly regulated in normal cells, but it is overactivated in cancer cells. Recently, several studies have indicated that microRNAs (miRNAs) play a critical role in the regulation of mTOR and mTOR‐associated processes, some acting as inhibitors and the others as activators. Although it is still in infancy, the strategy of combining both miRNAs and mTOR inhibitors might provide an approach to selectively sensitizing tumor cells to chemotherapy‐induced DNA damage and subsequently attenuating the tumor cell growth and apoptosis. Abstract : The mammalian target of rapamycin (mTOR) signaling pathway mediates various physiological and pathological processes, especially cell proliferation, protein synthesis, autophagy, and cancer development. Besides, microRNAs play a critical role in the regulation of mTOR and mTOR‐associated processes, some acting as inhibitors and the others as activators. Therefore, the strategy of combining both miRNAs and mTOR inhibitors might provide a new approach to cancer therapy.