ABC of multifaceted dystrophin glycoprotein complex (DGC). Issue 7 (22nd June 2017)

• Record Type: Journal Article
• Authors: Bhat, Hina F.; Mir, Saima S.; Dar, Khalid B.; Bhat, Zuhaib F.; Shah, Riaz A.; Ganai, Nazir A.
• Is Part Of: Journal of cellular physiology. Volume 233:Issue 7(2018:Jul.)
• Page Start: 5142
• Page End: 5159
• Publication Date: 2017-06-22
• Subjects: dystrophies -- dystrophin -- dystrophin associated complex (DGC) -- synaptic signaling; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.25982
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract : Dystrophin protein in association with several other cellular proteins and glycoproteins leads to the formation of a large multifaceted protein complex at the cell membrane referred to as dystrophin glycoprotein complex (DGC), that serves distinct functions in cell signaling and maintaining the membrane stability as well as integrity. In accordance with this, several findings suggest exquisite role of DGC in signaling pathways associated with cell development and/or maintenance of homeostasis. In the present review, we summarize the established facts about the various components of this complex with emphasis on recent insights into specific contribution of the DGC in cell signaling at the membrane. We have also discussed the recent advances made in exploring the molecular associations of DGC components within the cells and the functional implications of these interactions. Our review would help to comprehend the composition, role, and functioning of DGC and may lead to a deeper understanding of its role in several human diseases. Abstract : The dystrophin glycoprotein complex (DGC) is a membrane associated protein complex that plays a very crucial role in maintaining the integrity and stability of membranes. Growing evidence points toward a central role of DGC complex in membrane integrity, synapse, and crucial cell signaling pathways. Furthermore, a large number of muscular pathologies and synapse related disorders are being associated with mutations and/or deregulation of DGC signaling.