Hepatoprotective effects of phosphatidylserine liposomes on carbon tetrachloride‐induced hepatotoxicity in rats. Issue 7 (15th February 2019)

• Record Type: Journal Article
• Authors: Yousefi‐Manesh, Hasan; Shirooie, Samira; Partoazar, Alireza; Nikoui, Vahid; Estakhri, Mohammad Reza Abdollahzadeh; Bakhtiarian, Azam
• Is Part Of: Journal of cellular biochemistry. Volume 120:Issue 7(2019)
• Page Start: 11853
• Page End: 11858
• Publication Date: 2019-02-15
• Subjects: antioxidant -- CCl4 -- hepatoprotective -- liposome -- phosphatidylserine; Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.28464
• Languages: English
• ISSNs: 0730-2312

Abstract

Abstract: It has been proposed carbon tetrachloride (CCl4 ) intoxication due to the production of free radicals and serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) overload results hepatotoxicity. Phosphatidylserine (PS) has shown antioxidant activity in numerous studies. Therefore, this study was aimed to investigate the effects of PS liposomes treatment against the CCl4 ‐induced hepatotoxicity in a rat model. Male Wistar rats were treated with PS (10 mg/kg, oral) or phosphatidylcholine liposomes (PC) (10 mg/kg, oral) for 3 days before CCl4 (2 ml/kg; ip once on the third day) injection. The serum level of ALT, AST, and ALP were measured. Also, antioxidant assays were performed. Administration of PS with CCl4 significantly inhibited alterations in the serum levels of AST, ALP ( ** P < 0.01), and ALT ( *** P < 0.001) compared with control group. Furthermore, measurement of malondialdehyde (MDA), catalase (CAT), and superoxide dismutase (SOD) levels indicated that PS significantly reduced reactive oxygen species. The results of the present study showed the hepatoprotective effects of PS against CCl4 ‐induced hepatotoxicity in rats. Abstract : Carbon tetrachloride (CCl4 ) has hepatotoxic effects by producing free radicals and reactive oxygen species. Phosphatidylserine shows beneficial effects on hepatotoxicity induced by CCl4 .