326 Sleep Stages Variation in Intracranial Pressure and Pulse Amplitude. (April 2023)
- Record Type:
- Journal Article
- Title:
- 326 Sleep Stages Variation in Intracranial Pressure and Pulse Amplitude. (April 2023)
- Main Title:
- 326 Sleep Stages Variation in Intracranial Pressure and Pulse Amplitude
- Authors:
- Darie, Lucia
Bancroft, Matthew
Glorioso, Dolora
Pandit, Anand
Moncur, Eleanor
Thorne, Lewis
Radcliffe, Jeremy
Eriksson, Sofia
Watkins, Laurence Dale
Toma, Ahmed - Abstract:
- Abstract : INTRODUCTION: It is thought that CSF pulsatility has an important role in brain physiology during sleep. Yet few studies have looked into changes of ICP and pulsatility during sleep. METHODS: A single centre prospective cohort study. Patients undergoing 24 h ICP monitoring for suspected CSF dynamic disorders underwent concomitant polysomnography. Clinical and radiological presentation were derived from the patient's records. Aggregate mean ICP and pulse amplitude (mPA) values were recorded for each sleep stage. Sleep staging was performed in conformity with the AASM guidelines. Within subject values were compared using repeated-measures, one-way ANOVA. Post-hoc paired t-tests were used to compare sleep stages between groups corrected for multiple comparisons (Benjamini-Hochberg method). RESULTS: A total of 12 patients (10 females, 2 males; mean age 40.8 years, SD+/- 12.9) with complete data were analysed. There were significant differences in mean ICP between sleep stages (F(3, 33) = 10.7, p < 0.00001). Post-hoc paired t-tests revealed significant differences between rapid eye movement (REM; mean ICP 14.4 mmHg) and all other sleep stages (mean ICP/N1 = 12.0 mmHg, t = -3.6, p = 0.004; ICP/N2 = 11.8 mmHg, t = -4.3, p = 0.001; ICP/N3 = 12.3 mmHg, t = -3.5, p = 0.004). Significant differences were also found in mPA between sleep stages (F(3, 33) = 5.7, p = 0.003) confirmed on post-hoc paired t-tests: REM (mean mPA 5.5 mmHg and all other sleep stages: mPA/N1 = 4.7Abstract : INTRODUCTION: It is thought that CSF pulsatility has an important role in brain physiology during sleep. Yet few studies have looked into changes of ICP and pulsatility during sleep. METHODS: A single centre prospective cohort study. Patients undergoing 24 h ICP monitoring for suspected CSF dynamic disorders underwent concomitant polysomnography. Clinical and radiological presentation were derived from the patient's records. Aggregate mean ICP and pulse amplitude (mPA) values were recorded for each sleep stage. Sleep staging was performed in conformity with the AASM guidelines. Within subject values were compared using repeated-measures, one-way ANOVA. Post-hoc paired t-tests were used to compare sleep stages between groups corrected for multiple comparisons (Benjamini-Hochberg method). RESULTS: A total of 12 patients (10 females, 2 males; mean age 40.8 years, SD+/- 12.9) with complete data were analysed. There were significant differences in mean ICP between sleep stages (F(3, 33) = 10.7, p < 0.00001). Post-hoc paired t-tests revealed significant differences between rapid eye movement (REM; mean ICP 14.4 mmHg) and all other sleep stages (mean ICP/N1 = 12.0 mmHg, t = -3.6, p = 0.004; ICP/N2 = 11.8 mmHg, t = -4.3, p = 0.001; ICP/N3 = 12.3 mmHg, t = -3.5, p = 0.004). Significant differences were also found in mPA between sleep stages (F(3, 33) = 5.7, p = 0.003) confirmed on post-hoc paired t-tests: REM (mean mPA 5.5 mmHg and all other sleep stages: mPA/N1 = 4.7 mmHg, t = -2.3, p = 0.04; mPA/N2 = 4.3 mmHg, t = -2.7, p = 0.02; mPA/N3 = 4.5 mmHg, t = -2.3, p = 0.04). CONCLUSIONS: REM is characterized by higher ICP and mPA values, result confirmed in near-normal patients included in this cohort. … (more)
- Is Part Of:
- Neurosurgery. Volume 69(2023)Supplement 1
- Journal:
- Neurosurgery
- Issue:
- Volume 69(2023)Supplement 1
- Issue Display:
- Volume 69, Issue 1 (2023)
- Year:
- 2023
- Volume:
- 69
- Issue:
- 1
- Issue Sort Value:
- 2023-0069-0001-0000
- Page Start:
- 48
- Page End:
- 48
- Publication Date:
- 2023-04
- Subjects:
- Nervous system -- Surgery -- Periodicals
617.48005 - Journal URLs:
- https://academic.oup.com/neurosurgery ↗
http://www.neurosurgery-online.com ↗
https://journals.lww.com/neurosurgery/pages/default.aspx ↗
http://journals.lww.com ↗ - DOI:
- 10.1227/neu.0000000000002375_326 ↗
- Languages:
- English
- ISSNs:
- 0148-396X
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6081.582000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 26180.xml