316 Neurosurgical Federated Learning: A Multi-Center Collaboration to Detect Intracranial Hemorrhage Without Directly Sharing Data. (April 2023)

• Record Type: Journal Article
• Authors: Cheung, Alexander; Moin, Mustafa Nasir; Kwon, Fred; Guan, Jiahui; Liu, Chris; Jiang, Lavender; Raimondo, Christian; Chotai, Silky; Chambless, Lola Blackwell; Ahmad, Hasan S.; Chauhan, Daksh; Yoon, Jang Won; Hollon, Todd Charles; Buch, Vivek; Kondziolka, Douglas; Chen, Dinah; Al-Aswad, Lama; Aphinyanaphongs, Yindalon; Oermann, Eric
• Is Part Of: Neurosurgery. Volume 69(2023)Supplement 1
• Page Start: 44
• Page End: 45
• Publication Date: 2023-04
• Subjects: Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1227/neu.0000000000002375_316
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract : INTRODUCTION: The development of accurate and generalizable machine learning algorithms requires sufficient quantities of diverse data. This poses a challenge in healthcare due to the sensitive and siloed nature of biomedical information. Decentralized algorithms through a federated learning (FL) paradigm avoid the need for data aggregation by instead distributing algorithms to the data itself before centrally updating one global model. METHODS: Five academic neurosurgery departments across the US collaborated to establish a federated network using computed tomography (CT) scans for prototyping. We trained a convolutional neural network to detect the presence of ICH through FL and benchmarked this against a standard, centralized training approach. Models were validated on each site's data and tested on a held-out dataset to determine the area under the ROC curve (AUROC). RESULTS: A federated network of practicing neurosurgeon-scientists was successfully initiated and used to train a model for predicting ICH across the US. The federated model achieved an average AUROC of 0.9487 at predicting all types of ICH compared to a benchmark non-FL model AUROC of 0.9753, although performance varied by hemorrhage subtype. Subdural bleeds had the lowest AUROC (0.9257) while intraventricular bleeds had the highest (0.9751) on hold-out data. The global FL model consistently achieved top-three performance (of five) when validated on data from each site, suggesting improved generalizability. A qualitative survey of participants revealed that a majority found the process of connecting to the federated network easy. CONCLUSIONS: This study demonstrates the feasibility of implementing a federated network for multi-institutional collaboration amongst clinicians and using FL to conduct machine learning research without the transfer of data between sites, thereby opening up a new paradigm for neurosurgical collaboration.