The role of venous anatomy in guiding treatment approach for dural arteriovenous fistulas of the craniocervical junction; case series & systematic review. (April 2023)

• Record Type: Journal Article
• Authors: Javed, Kainaat; Kirnaz, Sertac; Zampolin, Richard; Khatri, Deepak; Fluss, Rose; Fortunel, Adisson; Holland, Ryan; Hamad, Mousa K.; Inocencio, Julio Fidel Ko; Stock, Ariel; Scoco, Aleka; De La Garza Ramos, Rafael; Ahmad, Samuel; Haranhalli, Neil; Altschul, David
• Is Part Of: Journal of clinical neuroscience. Volume 110(2023)
• Page Start: 27
• Page End: 38
• Publication Date: 2023-04
• Subjects: Dural arteriovenous fistula -- Craniocervical junction -- Microsurgery -- Embolization; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2023.02.004
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: DAVF of the craniocervical junction can have different venous drainage patterns. The venous drainage can be inferior, superior or both. The anatomy of the DAVF predicts the clinical presentation of the patient. Patients with superior drainage are more likely to present with a hemorrhage whereas patients with inferior drainage tend to present with myelopathy. In our paper, we propose a novel classification system in which DAVF of the craniocervical junction can be grouped into three types and for each type, we present a treatment paradigm. Microsurgery remains an effective treatment option. There is an emerging role of transvenous embolization particularly for superior draining DAVF. Abstract: Background: Dural arteriovenous fistulas (DAVF) of the craniocervical junction (CCF) are an uncommon entity with the following venous drainage pattern: inferior, superior and mixed. Patients may present with subarachnoid hemorrhage, myelopathy or brainstem dysfunction. CCJ DAVF can be treated with microsurgery or with transarterial and transvenous embolization, depending on the venous drainage pattern. We present our institutional experience of treating CCJ DAVFs along with a systematic review of the literature. Methods: Six patients with CCJ DAVF were treated at our institution over five years. Data was collected using electronic medical record review. Systematic review was performed on CCJ DAVF using the PubMed database from 1990 to 2021. We characterized venous drainage patterns, treatment choices, and outcomes to create a classification system. Results: 50 case reports, consisting of 115 patients, were included in our review. 61 (53.0 %) patients had inferior drainage while 32 (27.8 %) patients had superior drainage and 22 (19.2 %) patients had mixed venous drainage. Patients with inferior drainage had the fistulous connection at the foramen magnum while patients with superior drainage had a fistulous connection at C1-C2 (p value = 0.026). Patients with inferior drainage were more likely to present with myelopathy while patients with superior drainage presented with hemorrhage (p value = 0.000). Conclusions: Classifying the venous drainage pattern is essential in making treatment decision. Transvenous embolization works best with large superior venous drainage. If endovascular treatment is not an option, then surgical clipping can achieve successful cure. Transarterial embolization is a reasonable option in cases with a large arterial feeder.