Nickel-catalyzed desulfonylative olefination of β-hydroxysulfones. Issue 6 (20th February 2023)

• Record Type: Journal Article
• Authors: Cook, Adam; Bezaire, Maxwell; Newman, Stephen G.
• Is Part Of: Organic chemistry frontiers. Volume 10:Issue 6(2023)
• Page Start: 1399
• Page End: 1404
• Publication Date: 2023-02-20
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo01999j
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A Ni-catalyzed C–O bond activation is used to access alkenes directly from β-hydroxysulfones. Abstract : Disclosed herein is a protocol that permits the desulfonylative olefination of β-hydroxy, β-keto and β-ethereal sulfones through the activity of a Ni-NHC catalyst. Employing this method allows for the reliable synthesis of both nonconjugated and conjugated olefins with mono, di, tri or tetrasubstitution patterns. A brief mechanistic exploration of this reaction provides evidence to support the existence of both radical and organonickel intermediates en route to form product.