Development of highly sensitive electrochemical sensor for antibiotic drug ronidazole based on spinel cobalt oxide nanorods embedded with hexagonal boron nitride. (1st April 2023)

• Record Type: Journal Article
• Authors: Karupppaiah, Balamurugan; Jeyaraman, Anupriya; Chen, Shen-Ming; Huang, Yu-Ching
• Is Part Of: Electrochimica acta. Volume 446(2023)
• Publication Date: 2023-04-01
• Subjects: Ronidazole -- Electrochemical sensor -- Cobalt oxide -- Boron nitride -- Highest sensitivity; Electrochemistry -- Periodicals; Electrochemistry, Industrial -- Periodicals; 541.37
• DOI: 10.1016/j.electacta.2023.142008
• Languages: English
• ISSNs: 0013-4686

Abstract

Research highlights: Composite of cobalt oxide nanorods (CoCo2 O4 NRs), and hexagonal boron nitride were prepared. A new electrochemical sensor was reported based on CoCo2 O4 NRs/h-BN for antibiotic Ronidazole detection. The CoCo2 O4 NRs/h-BN exhibits good electrocatalytic activity towards Ronidazole detection. The constructed electrode owns a LOD (3 nM) and higher sensitivity (5.845 µA µM −1 cm −2 ). The good recovery results were obtained for ronidazole determination in real sample analysis. Abstract: The construction of highly sensitive electrochemical sensors is essential for the determination of pharmaceutical drugs. Because pharmaceutical drugs and their metabolites are significantly polluting the aqueous systems. Herein, we have developed a highly sensitive electrochemical sensor for the determination of veterinary antibiotic drug ronidazole (RNZ). The electrode has fabricated based on cobalt oxide nanorods integrated hexagonal boron nitride-modified glassy carbon electrode (CoCo2 O4 NRs/h-BN/GCE). The CoCo2 O4 nanorods were prepared by cetyl trimethyl ammonium bromide (CTAB) assisted hydrothermal method and the CoCo2 O4 NRs/h-BN composite was prepared using an ultra-sonication/stirring process. The as-prepared catalysts were confirmed by p-XRD, FT-IR, XPS, and FE-SEM analysis. The electrochemical performance of the catalyst was analyzed by using CV, and DPV techniques. CoCo2 O4 NRs/h-BN/GCE shows the highest electrocatalytic activity for the sensing of RNZ. Moreover, the nanocomposite shows lower LOD (3 nM) and highest sensitivity (5.845 µA µM −1 cm −2 ) for RNZ determination. Graphical abstract: Image, graphical abstract