Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography. Issue 21 (21st February 2023)

• Record Type: Journal Article
• Authors: Dickmann, Catherine G. Fitzgerald; McDonald, Alexander F.; Huynh, Nhi; Rigopoulos, Angela; Liu, Zhanqi; Guo, Nancy; Osellame, Laura D.; Gorman, Michael A.; Parker, Michael W.; Gan, Hui K.; Scott, Andrew M.; Ackermann, Uwe; Burvenich, Ingrid J. G.; White, Jonathan M.
• Is Part Of: Chemical communications. Volume 59:Issue 21(2023)
• Page Start: 3126
• Page End: 3129
• Publication Date: 2023-02-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc04813b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A fluorine-18 labelled probe was developed to target bromodomain and extraterminal (BET) proteins for molecular imaging of cancer with positron emission tomography. Abstract : Bromodomain and extraterminal (BET) proteins, a family of epigenetic regulators, have emerged as important oncology drug targets. BET proteins have not been targeted for molecular imaging of cancer. Here, we report the development of a novel molecule radiolabelled with positron emitting fluorine-18, [ 18 F]BiPET-2, and its in vitro and preclinical evaluation in glioblastoma models.