Recent advances in the discovery, biosynthesis, and therapeutic potential of isocoumarins derived from fungi: a comprehensive update. Issue 12 (10th March 2023)

• Record Type: Journal Article
• Authors: Tammam, Mohamed A.; Gamal El-Din, Mariam I.; Abood, Amira; El-Demerdash, Amr
• Is Part Of: RSC advances. Volume 13:Issue 12(2023)
• Page Start: 8049
• Page End: 8089
• Publication Date: 2023-03-10
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2ra08245d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : This review article provides an intensive state-of-the-art over the period 2000–2022 centred around the discovery, classifications, biosynthetic pathways and therapeutic potentialities of 351 structurally diverse fungal containing-isocoumarins. Abstract : Microorganisms still remain the main hotspots in the global drug discovery avenue. In particular, fungi are highly prolific producers of vast structurally diverse specialized secondary metabolites, which have displayed a myriad of biomedical potentials. Intriguingly, isocoumarins is one distinctive class of fungal natural products polyketides, which demonstrated numerous remarkable biological and pharmacological activities. This review article provides a comprehensive state-of-the-art over the period 2000–2022 about the discovery, isolation, classifications, and therapeutic potentials of isocoumarins exclusively reported from fungi. Indeed, a comprehensive list of 351 structurally diverse isocoumarins were documented and classified according to their fungal sources [16 order/28 family/55 genera] where they have been originally discovered along with their reported pharmacological activities wherever applicable. Also, recent insights around their proposed and experimentally proven biosynthetic pathways are also briefly discussed.