Novel markers of ventricular repolarization are associated with mortality in patients undergoing surgical aortic valve replacement for severe aortic stenosis. Issue 12 (10th October 2021)

• Record Type: Journal Article
• Authors: Avci, Yalcin; Demir, Ali R.; Bulut, Umit; Demirci, Gökhan; Karakurt, Seda T.; Sancar, Kadriye M.; Aktemur, Tugba; Uygur, Begüm; Ersoy, Burak; Erturk, Mehmet
• Is Part Of: Journal of cardiac surgery. Volume 36:Issue 12(2021)
• Page Start: 4591
• Page End: 4596
• Publication Date: 2021-10-10
• Subjects: aortic stenosis -- aortic valve replacement -- Tp‐e interval -- Tp‐e/QT ratio -- Tp‐e/QTc ratio; Heart -- Surgery -- Periodicals; 617.412005
• DOI: 10.1111/jocs.16063
• Languages: English
• ISSNs: 0886-0440

Abstract

Abstract: Introduction: Aortic stenosis (AS) is the most common degenerative valvular heart disease that can affect left ventricular functions. Tp‐e interval and Tp‐e/QT ratio is a novel repolarization marker which is associated with adverse cardiovascular events in several cardiovascular diseases. In our study, our aim is to investigate the prognostic effect of Tp‐e interval, Tp‐e/QT and Tp‐e/QTc ratios on mortality in patients who underwent successful surgical aortic valve replacement (AVR). Methods: A total of three hundred seventy‐five patients undergoing successful surgical AVR were included in this study. Then, patients were divided into two groups according to mortality as group 1 without mortality (342 patients) and group 2 with mortality (33 patients). Tp‐e interval, Tp‐e/QT, and Tp‐e/QTc ratios were calculated for both groups. Results: Tp‐e interval (71 (63.7–77); 86 (84–88), p < .001), Tp‐e/QT ratio (0.19 (0.17–0.20); 0.23 (0.22–0.23), p < .001) and Tp‐e/QTc ratio (0.17 ± 0.02; 0.21 ± 0.01, p < .001) were higher in group 2 compared to group 1. In multivariate logistic regression analyses Tp‐e interval (odds ratio [OR]: 1.315, 95% confidence interval [CI]: 1.203–1.437, p < .001), Tp‐e/QT ratio (OR: 7.334, 95% CI: 3.274–1.643, p < .001) and Tp‐e/QTc ratio (OR: 2.567, 95% CI: 4.106–1.605, p < .001) were found to be independent predictors of mortality. Additionally, a Kaplan‐Meier survival analysis also revealed that long term survival was found to be significantly decreased in patients with higher Tp‐e/QT ratio (Log‐Rank p < .001) and Tp‐e/QTc ratio (Log‐Rank p < .001). Conclusion: Tp‐e interval, Tp‐e dispersion, Tp‐e/QT, and Tp‐e/QTc ratios are associated with worse prognosis after surgical AVR in patients with severe AS. All of them are also independent predictors of mortality.