Fecal Microbiota Transplantation Across the Lifespan: Balancing Efficacy, Safety, and Innovation. (29th March 2023)

• Record Type: Journal Article
• Authors: Gulati, Ajay S.; Nicholson, Maribeth R.; Khoruts, Alexander; Kahn, Stacy A.
• Is Part Of: American journal of gastroenterology. Volume 118:Number 3(2023)
• Page Start: 435
• Page End: 439
• Publication Date: 2023-03-29
• Subjects: fecal microbiota transplant -- Clostridioides difficile -- biotherapeutics -- microbiota -- lifespan; Stomach -- Diseases -- Periodicals; Intestines -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Gastrointestinal Diseases -- Periodicals; Electronic journals; Periodicals; 616.33
• DOI: 10.14309/ajg.0000000000002167
• Languages: English
• ISSNs: 0002-9270

Abstract

Abstract : Fecal microbiota transplantation (FMT) is a rapidly growing therapy aimed at reconstituting the dysbiotic microbiota of a patient with the beneficial stool microbiota of a healthy individual. The efficacy rates of FMT are very robust for recurrent Clostridioides difficile infection in both children and adults. Although complications of FMT have been reported, it is generally believed to be a safe procedure. Novel indications for FMT are being studied, with the hope that ultimately it may be useful for a variety of disorders. As this field continues to grow, however, it is necessary to consider efficacy, safety, and innovation across the lifespan. There are unique concerns regarding FMT as it pertains to children, adults, and the elderly. In this review, we seek to update clinicians, researchers, and regulators on how these factors must be balanced across the lifespan as we move forward with this innovative therapy.