Alkyne Surrogates in Cycloaddition Reactions for the Preparation of Molecules of Interest. Issue 9 (6th August 2021)

• Record Type: Journal Article
• Authors: Amatore, Muriel; Parrain, Jean‐Luc; Commeiras, Laurent
• Is Part Of: Asian journal of organic chemistry. Volume 10:Issue 9(2021)
• Page Start: 2287
• Page End: 2299
• Publication Date: 2021-08-06
• Subjects: alkyne surrogate -- alkyne equivalent -- carbocycles -- cycloaddition -- heterocycles; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202100345
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: Although alkynes are very good partners for cycloaddition reactions, their use is often associated to several drawbacks, such as multi‐steps synthesis, selectivity and stability issues or difficulty to handle for alkynes with low boiling point. In this context, alkyne surrogates have emerged as alternative substitution partners unlocking new opportunities. This review intends to highlight the outstanding power and utility of such compounds for the preparation of high value molecules. Abstract : Although alkynes are very good partners for cycloaddition reactions, their use is often associated to several drawbacks, such as multi‐steps synthesis, selectivity and stability issues or difficulty to handle for alkynes with low boiling point. In this context, alkyne surrogates have emerged as alternative substitution partners unlocking new opportunities. This review intends to highlight the outstanding power and utility of such compounds for the preparation of high value molecules.