An Fe(iii)-catalyzed reduction radical tandem strategy to access poly-substituted β-alkenyl valerolactones. Issue 6 (17th February 2023)

• Record Type: Journal Article
• Authors: Li, Fu-Yu; Wang, Bei; Xu, Hong; Xiao, Yao; Huang, Dong-Wei; Wang, Ji-Yu
• Is Part Of: Organic chemistry frontiers. Volume 10:Issue 6(2023)
• Page Start: 1551
• Page End: 1556
• Publication Date: 2023-02-17
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo02038f
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : The convenient synthesis of structurally diverse and complex poly-substituted β-alkenyl valerolactones is first reported via the reduction radical tandem strategy of 2, 3-dienoates and allyl alcohols by Fe(iii )-catalysis. Abstract : The convenient synthesis of structurally diverse and complex poly-substituted β-alkenyl valerolactones is first reported via the reduction radical tandem strategy of 2, 3-dienoates and allyl alcohols by Fe(iii )-catalysis. Under Fe(iii ) catalysis, various allyl alcohols can simultaneously transform into alkyl radicals and allyl ester intermediates, which can form products via Michael addition. Interestingly, the method can also prepare spiro-valerolactones and cyclo-valerolactones. In addition, β-alkenyl valerolactones can be further transformed into unreported pyrazole lactone compounds.