Base Promoted Intramolecular O‐arylation For The Synthesis of Dibenzo[b, f]oxepinones Toward Dihydroartocarpol D. Issue 7 (2nd June 2021)

• Record Type: Journal Article
• Authors: Li, Kaili; Zhang, Kun; Huang, He; Zhang, Qianqian; Song, Chuanjun; Chang, Junbiao
• Is Part Of: Asian journal of organic chemistry. Volume 10:Issue 7(2021)
• Page Start: 1765
• Page End: 1772
• Publication Date: 2021-06-02
• Subjects: dibenzo[b, f]oxepinone -- O-arylation -- transition metal free -- dihydroartocarpol D; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202100227
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: An efficient base‐promoted intramolecular O ‐arylation approach of 2‐halobenzyl 2‐hydroxyphenyl ketones toward the synthesis of dibenzo[ b, f ]oxepinones has been developed. The products are obtained in good to excellent isolated yields. Further extension of the strategy to the total synthesis of dihydroartocarpol D has been described. Abstract : We have developed a novel base‐promoted O ‐arylation approach for the synthesis of dibenzo[ b, f ]oxepinones. The strategy is applied as a key step for the synthesis of dihydroartocarpol D.