Cover Feature: Enhancing Photostability of a Coumarin Dye by Self‐inclusion into a Cyclodextrin Cavity in Aqueous Solution and Living Cells (Asian J. Org. Chem. 12/2020). Issue 12 (7th December 2020)

• Record Type: Journal Article
• Authors: Shigemitsu, Hajime; Matsuda, Keigo; Mori, Tadashi; Nakatsuji, Hirotaka; Matsusaki, Michiya; Kida, Toshiyuki
• Is Part Of: Asian journal of organic chemistry. Volume 9:Issue 12(2020)
• Page Start: 1870
• Page End: 1870
• Publication Date: 2020-12-07
• Subjects: cyclodextrin -- photostability -- coumarin dye -- self-inclusion -- bioimaging; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202000640
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract : Photostable organic dyes are required for long‐time or super‐resolution bioimaging. In this work, an effective improvement of photostability of a coumarin dye (Pacific Blue (PB )) is demonstrated by steric protection using a cyclodextrin. The PB ‐conjugated cyclodextrin (PB‐CD ) showed suppression of photodegradation and reactive oxygen species (ROS) generation during photoirradiation as compared to PB . The effects afford an improvement of photostability of PB dye. Finally, the photostability of PB‐CD was evaluated using confocal laser scanning microscopy (CLSM) and a significant improved effect was proven even in living cells. More information can be found in the Communication by Hajime Shigemitsu, Toshiyuki Kida, et al.