Reinforcing supramolecular hyaluronan hydrogels via kinetically interlocking multiple-units strategy. (15th June 2023)

• Record Type: Journal Article
• Authors: Chen, Ruofan; Li, Yujie; Jin, Yu; Sun, Yawei; Zhao, Zhiyong; Xu, Yun; Xu, Jiang-Fei; Dong, Yuanchen; Liu, Dongsheng
• Is Part Of: Carbohydrate polymers. Volume 310(2023)
• Publication Date: 2023-06-15
• Subjects: Ad adamantane -- BOC2O Di-tert-butyl decarbonate -- CB[8] cucurbit[8]uril -- CBHA hydrogel hyaluronan hydrogel mono-crosslinked by CB[8] -- DS degree of substitution -- diHA-n hyaluronan hydrogel double-crosslinked by CB[8] and oCD (n represented the equivalents of oCD) -- DMAP 4-Dimethylaminopyridine -- DN hydrogels double network hydrogels -- ESI electrospray ionization -- GlcA ᴅ-glucuronic acid -- GlcNAc N-acetyl-ᴅ-glucosamine -- HA hyaluronan/hyaluronic acid -- KIMU kinetically interlocking multiple-units -- NMR nuclear magnetic resonance -- oCD β-CD oligomer -- PAHA Phe and Ad double-modified HA -- Phe phenylalanine -- PMDTA N, N, N′, N′, N′′- pentamethyldiethylenetriamine -- tTs principle time-temperature superposition principle -- β-CD β-cyclodextrin; Hyaluronan -- Supramolecular hydrogels -- Kinetically interlocking multiple-units (KIMU) effects -- Host-guest interaction; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2023.120703
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Supramolecular hydrogels exhibit promising potential in biological and clinical fields due to their special dynamic properties. However, most existing supramolecular hydrogels suffer from poor mechanical strength, which severely limits their applications. Here in this study, the Kinetically Interlocking Multiple-Units (KIMU) strategy was applied to the hyaluronan networks by introducing different supramolecular interaction motifs in an organized and alternative manner. Our strategy successfully elevated the energy barrier of crosslinker dissociation to 103.0 kJ mol -1 and increased the storage modulus of hydrogels by 78 % with the intrinsic dynamic properties preserved. It can be expected that this method would bring a convenient and effective route to fabricate novel supramolecular materials with excellent mechanical properties. Graphical abstract: Unlabelled Image