Design, synthesis of new phenyl acetylene and isoxazole analogues of arjunolic acid as potent tyrosinase and alpha glucosidase inhibitors. Issue 7 (3rd April 2023)

• Record Type: Journal Article
• Authors: Olanipekun, Bolatito Eunice; Ponnapalli, Mangala Gowri; Patel, Hemendra Kumar; Munipalle, Kiran; Shaik, Karimulla
• Is Part Of: Natural product research. Volume 37:Issue 7(2023)
• Page Start: 1092
• Page End: 1097
• Publication Date: 2023-04-03
• Subjects: Arjunolic acid -- α-glucosidase inihibition -- tyrosinase inhibition; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1986817
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A series of new phenyl acetylene and isoxazole analogues of arjunolic acid were designed, synthesized and evaluated (3 –8 ) for their tyrosinase and alpha glucosidase inhibitory potential. All the tested analogues exhibited stronger inhibitory activity than the standard drug or parent compound. Of these, compound (7 ) displayed the most potent tyrosinase inhibitory action with IC50 (14.3 ± 7.6) of about three folds more than the standard drug, kojic acid (41.5 ± 1.0). Further, compound (8 ) (14.5 ± 0.15) possessed the potent alpha glucosidase inhibitory action with IC50 value comparable to that of standard, acarbose (10.4 ± 0.06). Henceforth, compounds (7 ) and (8 ) are promising candidates for further studies. Graphical Abstract: UF0001