IL-1R8: A molecular brake of anti-tumor and anti-viral activity of NK cells and ILC. (March 2023)

• Record Type: Journal Article
• Authors: Mariotti, Francesca R.; Supino, Domenico; Landolina, Nadine; Garlanda, Cecilia; Mantovani, Alberto; Moretta, Lorenzo; Maggi, Enrico
• Is Part Of: Seminars in immunology. Volume 66(2023)
• Publication Date: 2023-03
• Subjects: ACT Adoptive Cell Transfer -- AMPK AMP-activated protein Kinase -- CF Cystic fibrosis -- CLL chronic lymphocytic leukemia -- CMV cytomegalovirus -- DAMPs damaged-associated molecular patterns -- DCs dendritic cells -- DNAM-1 DNAX Accessory Molecule-1 -- DSS dextran sodium sulphate -- ERK Extracellular-signal regulated kinase -- GSK3β glycogen kinase 3β -- GZMB Granzyme B -- HDM house dust mice -- HIV Human immunodeficiency virus -- HLA Human Leukocyte Antigens -- IC inhibitory checkpoint -- IFN-γ Interferon γ -- IL-1Rs Interleukin-1 receptor -- IL-1R8L1 IL-1R8 long isoform -- ILC Innate Lymphoid cell -- ILC1 group 1 ILCs -- ILC2 group 2 ILCs -- ILC3 group 3 ILCs -- iNKR HLA-specific inhibitory NK receptors -- IRAK interleukin-1 receptor-associated kinase -- JNKs c-Jun N-terminal kinases -- KLRG1 Killer Cell Lectin Like Receptor G1 -- LPS lipopolysaccharide -- LTi lymphoid tissue-inducer cells -- MAPK Mitogen-activated protein kinases -- MCMV murine cytomegalovirus -- MyD88 Myeloid differentiation primary response 88 -- mTOR mammalian target of rapamycin -- NCRs natural cytotoxicity receptors -- NK Natural Killer -- NKG2D Natural Killer Group 2D -- NF-kB nuclear factor kappa-light-chain-enhancer of activated B cells -- PAMPs pathogen-associated molecular patterns -- PGE2 prostaglandin 2 -- PsA psoriatic arthritis -- PTEN Phosphatase and TENsin homolog -- RA rheumatoid arthritisS6:S6 kinase -- SLE systemic lupus erythematosus -- STAT3 Signal Transducer And Activator Of Transcription 3 -- TI Trained Immunity -- TLRs Toll-Like Receptors -- TRAF6 tumor necrosis factor receptor-associated factor 6 -- USP13 Ubiquitin Specific Peptidase 13; IL-1R8 -- IL-37 -- NK and ILC cell function -- Inhibitory receptor -- Infections -- Tumor Immunotherapy; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Immunity -- Periodicals; Immunologie -- Périodiques; Electronic journals; 616.079
• DOI: 10.1016/j.smim.2023.101712
• Languages: English
• ISSNs: 1044-5323

Abstract

Abstract: Interleukin-1 receptor family members (ILRs) and Toll-Like Receptors (TLRs) play pivotal role in immunity and inflammation and are expressed by most cell types including cells of both the innate and adaptive immune system. In this context, IL-1 superfamily members are also important players in regulating function and differentiation of adaptive and innate lymphoid cells. This system is tightly regulated in order to avoid uncontrolled activation, which may lead to detrimental inflammation contributing to autoimmune or allergic responses. IL-1R8 (also known as TIR8 or SIGIRR) is a member of the IL-1R family that acts as a negative regulator dampening ILR and TLR signaling and as a co-receptor for human IL-37. Human and mouse NK cells, that are key players in immune surveillance of tumors and infections, express high level of IL-1R8. In this review, we will summarize our current understanding on the structure, expression and function of IL-1R8 and we will also discuss the emerging role of IL-1R8 as an important checkpoint regulating NK cells function in pathological conditions including cancer and viral infections.