Clinical expert consensus on the assessment and protection of pancreatic islet β-cell function in type 2 diabetes mellitus. (March 2023)

• Record Type: Journal Article
• Authors: Zhu, Jian; Han, Junfeng; Liu, Liehua; Liu, Yu; Xu, Wen; Li, Xiaomu; Yang, Lin; Gu, Yong; Tang, Wei; Shi, Yongquan; Ye, Shandong; Hua, Fei; Xiang, Guangda; Liu, Ming; Sun, Zilin; Su, Qing; Li, Xiaoying; Li, Yuxiu; Li, Yanbing; Li, Hong; Li, Yiming; Yang, Tao; Yang, Jing; Shi, Lixin; Yu, Xuefeng; Chen, Li; Shao, Jiaqing; Liang, Jun; Han, Xiao; Xue, Yaomin; Ma, Jianhua; Zhu, Dalong; Mu, Yiming;
• Is Part Of: Diabetes research and clinical practice. Volume 197(2023)
• Publication Date: 2023-03
• Subjects: Islets -- β-cell -- Functional assessment -- Weight loss -- Intensive insulin therapy -- Expert consensus; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2023.110568
• Languages: English
• ISSNs: 0168-8227

Abstract

Abstract: Islet β-cell dysfunction is a basic pathophysiological characteristic of type 2 diabetes mellitus (T2DM). Appropriate assessment of islet β-cell function is beneficial to better management of T2DM. Protecting islet β-cell function is vital to delay the progress of type 2 diabetes mellitus. Therefore, the Pancreatic Islet β-cell Expert Panel of the Chinese Diabetes Society and Endocrinology Society of Jiangsu Medical Association organized experts to draft the " Clinical expert consensus on the assessment and protection of pancreatic islet β-cell function in type 2 diabetes mellitus." This consensus suggests that β-cell function can be clinically assessed using blood glucose-based methods or methods that combine blood glucose and endogenous insulin or C-peptide levels. Some measures, including weight loss and early and sustained euglycemia control, could effectively protect islet β-cell function, and some newly developed drugs, such as Sodium-glucose cotransporter-2 inhibitor and Glucagon-like peptide-1 receptor agonists, could improve islet β-cell function, independent of glycemic control.