Influence of dynamic compressive loading on the in vitro degradation behavior of pure PLA and Mg/PLA composite. (December 2017)

• Record Type: Journal Article
• Authors: Li, Xuan; Qi, Chenxi; Han, Linyuan; Chu, Chenglin; Bai, Jing; Guo, Chao; Xue, Feng; Shen, Baolong; Chu, Paul K.
• Is Part Of: Acta biomaterialia. Volume 64(2017)
• Page Start: 269
• Page End: 278
• Publication Date: 2017-12
• Subjects: Dynamic compressive loading -- Mg/PLA -- Internal fixation implants -- Load frequency -- Degradation kinetics; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1016/j.actbio.2017.08.004
• Languages: English
• ISSNs: 1742-7061

Abstract

Graphical abstract: Abstract: The effects of dynamic compressive loading on the in vitro degradation behavior of pure poly-lactic acid (PLA) and PLA-based composite unidirectionally reinforced with micro-arc oxidized magnesium alloy wires (Mg/PLA) are investigated. Dynamic compressive loading is shown to accelerate degradation of pure PLA and Mg/PLA. As the applied stress is increased from 0.1 MPa to 0.9 MPa or frequency from 0.5 Hz to 2.5 Hz, the overall degradation rate goes up. After immersion for 21 days at 0.9 MPa and 2.5 Hz, the bending strength retention of the composite and pure PLA is 60.1% and 50%, respectively. Dynamic loading enhances diffusion of small acidic molecules resulting in significant pH decrease in the immersion solution. The synergistic reaction between magnesium alloy wires and PLA in the composite is further clarified by electrochemical tests. The degradation behavior of the pure PLA and PLA matrix in the composite under dynamic conditions obey the first order degradation kinetics and a numerical model is postulated to elucidate the relationship of the bending strength, stress, frequency, and immersion time under dynamic conditions. Statement of significance: We systematically study the influence of dynamic loading on the degradation behavior of pure PLA and Mg/PLA. Dynamic compressive loading is shown to accelerate degradation of pure PLA and Mg/PLA. The synergistic reaction between magnesium alloy wires and PLA in the composite is firstly clarified by electrochemical tests. The degradation behavior of the pure PLA and PLA matrix in the composite under dynamic conditions obey the first order degradation kinetics. Then, a numerical model is postulated to elucidate the relationship of the bending strength, stress, frequency, and immersion time under dynamic conditions.