Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease. (20th March 2023)

• Record Type: Journal Article
• Authors: Valitutti, Francesco; Leonard, Maureen M.; Kenyon, Victoria; Montuori, Monica; Piemontese, Pasqua; Francavilla, Ruggiero; Malamisura, Basilio; Norsa, Lorenzo; Calvi, Angela; Lionetti, Maria Elena; Baldassarre, Mariella; Trovato, Chiara Maria; Perrone, Michela; Passaro, Tiziana; Sansotta, Naire; Crocco, Marco; Morelli, Annalisa; Raguseo, Lidia Celeste; Malerba, Federica; Elli, Luca; Cristofori, Fernanda; Catassi, Carlo; Fasano, Alessio
• Is Part Of: American journal of gastroenterology. Volume 118:Number 3(2023)
• Page Start: 574
• Page End: 577
• Publication Date: 2023-03-20
• Subjects: celiac disease -- potential celiac disease -- anti-transglutaminase antibodies -- anti-deamidated gliadin peptides antibodies -- infant; Stomach -- Diseases -- Periodicals; Intestines -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Gastrointestinal Diseases -- Periodicals; Electronic journals; Periodicals; 616.33
• DOI: 10.14309/ajg.0000000000002192
• Languages: English
• ISSNs: 0002-9270

Abstract

Abstract : INTRODUCTION: The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk. METHODS: A subgroup from an ongoing, international prospective study of children at risk of CD was classified according to an early trajectory of deamidated gliadin peptides (DGPs) immunoglobulin (Ig) G and clinical outcomes (CD, potential CD, and CD autoimmunity). RESULTS: Thirty-eight of 325 children developed anti-tissue transglutaminase IgA antibody (anti-tTG IgA) seroconversion. Twenty-eight of 38 children (73.6%) showed an increase in anti-DGPs IgG before their first anti-tTG IgA seroconversion. DISCUSSION: Anti-DGPs IgG can represent an early preclinical biomarker predicting CD onset in children at risk.