Amidation Reaction of Quinoline‐3‐carboxylic Acids with Tetraalkylthiuram Disulfides under Simple Conditions: A facile Synthesis of Quinoline‐3‐carboxamides. Issue 12 (15th October 2020)

• Record Type: Journal Article
• Authors: Hu, Jingyan; Ye, Xiefeng; Hao, Shuai; Zhao, Qianrui; Zhao, Mingqin; Wei, Yuewei; Wu, Zhiyong; Wang, Na; Ji, Xiaoming
• Is Part Of: Asian journal of organic chemistry. Volume 9:Issue 12(2020)
• Page Start: 2191
• Page End: 2195
• Publication Date: 2020-10-15
• Subjects: quinoline-3-carboxamides -- quinoline-3-carboxylic acids -- tetraalkylthiuram disulfides -- C−N cross coupling reactions -- synthetic methods; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202000462
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: A highly efficient and simple procedure for the synthesis quinoline‐3‐carboxamides and their analogues via amidation reaction of quinoline‐3‐carboxylic acids with tetraalkylthiuram disulfides has been developed. The reaction proceeds efficiently under simple reaction conditions and features the generality of broad scope of substrates with good yields. This protocol provides a convenient procedure for the synthesis of various aza‐heteroaromatic carboxamides, which is of pharmaceutical interest. Abstract : A facile and convenient protocol for the synthesis of quinoline‐3‐carboxamides their analogues using tetraalkylthiuram disulfides as the amine sources under metal and additive free conditions has been achieved. This method allows the efficient coupling of diverse quinoline‐3‐carboxylic acids with tetraalkylthiuram disulfides through a simply mixing operation.