Social jetlag and mediterranean diet adherence are associated to liver fibrosis in patients with non-alcoholic fatty liver disease. (March 2023)

• Record Type: Journal Article
• Authors: Castelnuovo, G.; Caviglia, G.P.; Rosso, C.; Perez-Diaz-del-Campo, N.; Armandi, A.; Abdulle, A.; D'Amato, D.; Guariglia, M.; Poggiolini, I.; Olivero, A.; Abate, M.L.; Ribaldone, D.G.; Saracco, G.M.; Bugianesi, E.
• Is Part Of: Digestive and liver disease. Volume 55(2023)Supplement 1
• Page Start: S24
• Publication Date: 2023-03
• Subjects: Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2023.01.043
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract : Introduction and Aim: The discrepancy in a person's sleep pattern between working days and days off is called Social Jetlag (SJL). The aim of this work was to investigate the potential impact of Mediterranean Diet (MedDiet) on the risk of significant liver fibrosis (F≥2) in individuals with non-alcoholic fatty liver disease (NAFLD), according to SJL. Methods: A total of 148 patients diagnosed with NAFLD by ultrasound underwent assessment of liver stiffness + controlled attenuation parameter (CAP) (FibroScan® 530). F≥2 was defined by liver stiffness values ≥7.1kPa. The adherence to the MedDiet was assessed by the Mediterranean diet score questionnaire; low and high adherence were defined by the median value of the score. SJL was defined by the Munich Chronotype Questionnaire as the absolute difference between mid-sleep on free days and mid-sleep on workdays. According to the median value, we defined small and large SJL. Results: The median age was 52 (42-61.5) years and the main comorbidities were type-2 diabetes mellitus (T2DM) (26.35%), arterial hypertension (49.3%), dyslipidemia (64.9%), obstructive sleep apnea (OSAS) (5.4%), and depression (6.1%). Median liver stiffness and CAP values were 5.1kPa (F≥2; 13.5%) and 301db/m, respectively. The prevalence of large SJL was significantly higher in patients with F≤2 compared to those with F≥2 (57.46% vs. 28.57%, p=0.039), while no significant difference was found in the adherence to MedDiet between groups. At multivariate logistic regression analysis adjusted for sex, age, BMI, T2DM, OSAS, arterial hypertension, dyslipidemia, and depression, we found that the interaction between a large SJL and a high adherence to MedDiet was significantly associated to F≥2 (OR=0.02, p=0.049). Conclusion: Models integrating diet and SJL/sleep pattern characteristics may unveil potential pathogenetic mechanisms associated to liver fibrosis risk in patients with NAFLD. Italian Ministry for Education, University and Research (MIUR) under the programme "Dipartimenti di Eccellenza 2018-2022" n.D15D18000410001