Targeted Drug Delivery: Carbon‐Quantum‐Dots‐Loaded Mesoporous Silica Nanocarriers with pH‐Switchable Zwitterionic Surface and Enzyme‐Responsive Pore‐Cap for Targeted Imaging and Drug Delivery to Tumor (Adv. Healthcare Mater. 12/2016). Issue 12 (22nd June 2016)

• Record Type: Journal Article
• Authors: Liu, Zhongning; Chen, Xin; Zhang, Xiaojin; Gooding, John Justin; Zhou, Yongsheng
• Is Part Of: Advanced healthcare materials. Volume 5:Issue 12(2016)
• Page Start: 1380
• Page End: 1380
• Publication Date: 2016-06-22
• Subjects: dual‐stimuli responsiveness -- mesoporous silica nanocarriers -- selective cell imaging -- switchable antifouling -- tumor targeting drug delivery; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201670058
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : On page 1401 X. Chen, X. Zhang, Y. Zhou, and co‐workers describe the synthesis of mesoporous silica nanocarriers with pH‐switchable antifouling zwitterionic surfaces and blue fluorescence that are capable of enzyme‐responsive drug release. The system combines tumor treatment and tracking. It shows great potential for cancer treatment, since it exhibits prolonged circulation in the blood system with zero premature release while offering selective cellular uptake, tumor labeling, and intracellular drug release in tumor tissue.