Electrochemical Oxidative ortho‐Selective Trifluoromethylation of N‐Arylamides. Issue 5 (9th March 2022)

• Record Type: Journal Article
• Authors: Du, Jinze; Gao, Di; Zhang, Dong; Lin, Xinxin; Liu, Chengkou; Zhu, Ning; Yang, Zhao; He, Wei; Fang, Zheng; Guo, Kai
• Is Part Of: ChemElectroChem. Volume 9:Issue 5(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-09
• Subjects: C−H activation -- electrochemistry -- gram-scale -- metal-free -- trifluoromethylation; Electrochemistry -- Periodicals; 541.37
• DOI: 10.1002/celc.202101411
• Languages: English
• ISSNs: 2196-0216

Abstract

Abstract: A metal‐catalyst‐free and external‐oxidant‐free electrochemical oxidative radical C−H ortho ‐trifluoromethylation is presented. The reaction specifically occurred at the ortho ‐position of anilides without directing groups. Various anilides showed good tolerance to provide the desired products in moderate to good yields. In addition, the gram‐scale amplified product of benzanilide was obtained with a yield of 64 %, which proved that it has a certain application potential. Abstract : Efficient setup : An electrochemical approach for the synthesis of ortho ‐trifluoromethyl anilines with CF3 SO2 Na under metal‐catalyst‐free and oxidant‐free conditions was developed. And the reaction specifically occurred at the ortho ‐position of anilines without directing groups.