Clinical significance of immune checkpoint proteins in HPV-infected cervical cancer. Issue 4 (April 2023)

• Record Type: Journal Article
• Authors: Zou, Wenxue; Huang, Rui; Li, Peihang; Liu, Xiang; Huang, Qingyu; Yue, Jinbo; Liu, Chao
• Is Part Of: Journal of infection and public health. Volume 16:Issue 4(2023)
• Page Start: 542
• Page End: 550
• Publication Date: 2023-04
• Subjects: TIGIT T cell immunoreceptor with Ig and ITIM domain -- VISTA V-domain Ig suppressor of T cell activation -- LAG-3 lymphocyte-activation gene-3 -- CC cervical cancer -- HPV human papillomavirus -- PFS progression-free survival -- OS overall survival -- MHC class I major histocompatibility complex -- ICPs immune checkpoints -- PD-1 programmed cell death protein 1 -- CTLA-4 cytotoxic T-lymphocyte-associated antigen 4 -- NK natural killer -- Treg regulatory T -- Tfh follicular helper T -- PI3K phosphatidylinositol 3-kinase -- MAPK mitogen-activated protein kinase -- NF-κB nuclear factor-κB -- TCR T-cell receptor -- IL-2 interleukin-2 -- KPS Karnofsky Performance Scale -- IHC immunohistochemistry -- CPS combined positive score -- CCRT concurrent chemoradiotherapy; Cervical cancer -- HPV -- Immune checkpoints -- TIGIT -- VISTA -- LAG-3; Communicable diseases -- Periodicals; Public health -- Periodicals; Epidemiology -- Periodicals; Nosocomial infections -- Prevention -- Periodicals; Medical microbiology -- Periodicals; 614.4
• DOI: 10.1016/j.jiph.2023.01.019
• Languages: English
• ISSNs: 1876-0341

Abstract

Abstract: Objective: To investigate T cell immunoreceptor with Ig and ITIM domain (TIGIT), V-domain Ig suppressor of T cell activation (VISTA), and lymphocyte-activation gene-3 (LAG-3) expression in pathological tissue of human papillomavirus (HPV)-infected cervical cancer (CC) patients and their relationship with patient prognosis. Methods: Clinical data of 175 patients with HPV-infected CC were collected retrospectively. Tumor tissue sections were stained immunohistochemically for TIGIT, VISTA, and LAG-3. The Kaplan-Meier method calculated patient survival. Univariate and multivariate Cox proportional hazards models analyzed all potential risk factors for survival. Results: When combined positive score (CPS)= 1 was used as the cut-off value, the Kaplan-Meier survival curve showed that the progression-free survival (PFS) and overall survival (OS) of patients with positive expression of TIGIT and VISTA are shorter (both p < 0.05). Univariate COX regression analysis showed that the positive expression of TIGIT and VISTA are related to patient PFS and OS (both HR>1.0 and p < 0.05). Multivariate COX regression analysis showed that TIGIT-positive patients had shorter OS and VISTA-positive patients had shorter PFS (both HR>1.0 and p < 0.05). There is no significant correlation between LAG-3 expression and PFS or OS. When CPS= 10 was used as the cut-off value, Kaplan-Meier survival curve showed that TIGIT-positive patients had shorter OS ( p = 0.019). Univariate COX regression analysis showed that TIGIT-positive expression was associated with the OS of patients (HR=2.209, CI: 1.118–4.365, p = 0.023). However, multivariate COX regression analysis showed that TIGIT expression was not associated significantly with OS. There was no significant correlation between VISTA and LAG-3 expression and PFS or OS. Conclusion: TIGIT and VISTA are associated closely with HPV-infected CC prognosis and are effective biomarkers.