Quantitative imaging of fluorine in human teeth by cryogenic laser ionization time-of-flight mass spectrometry. Issue 3 (30th January 2023)

• Record Type: Journal Article
• Authors: Ma, Siyuan; Zhang, Zhenjian; Xu, Zhouyi; Qiu, Xiongwen; Hang, Wei
• Is Part Of: Journal of analytical atomic spectrometry. Volume 38:Issue 3(2023)
• Page Start: 595
• Page End: 602
• Publication Date: 2023-01-30
• Subjects: Atomic spectra -- Periodicals; Atomic absorption spectroscopy -- Periodicals; 543.0858
• DOI: 10.1039/d2ja00338d
• Languages: English
• ISSNs: 0267-9477

Abstract

Abstract : Cryogenic laser ionization time-of-flight mass spectrometry provides a new quantitative imaging technique to reveal F distribution in human teeth. Abstract : The scarcity of techniques for visualizing fluorine (F) hinders the comprehensive understanding of the role of anti-caries fluorides. This study introduced a liquid nitrogen cooling device into the laser ionization source to construct a novel cryogenic laser ionization time-of-flight mass spectrometry (Cryo-LI-TOFMS) imaging platform for F. The technique eliminated the interference of water-related species at m / z 19 and realized F imaging with a spatial resolution of 20 μm. The quantitative imaging of 9 major elements in human teeth, including F, confirmed the feasibility of this method and revealed teeth compositions and mineralization environment. The quantitative imaging of F in teeth treated with different topical anti-caries drugs or different application times clarified the site and time of drug action, providing a solid foundation and promising prospects for drug research.