Characterization of peptide O⋯HN hydrogen bonds via1H-detected 15N/17O solid-state NMR spectroscopy. Issue 21 (21st February 2023)

• Record Type: Journal Article
• Authors: Hung, Ivan; Mao, Wenping; Keeler, Eric G.; Griffin, Robert G.; Gor'kov, Peter L.; Gan, Zhehong
• Is Part Of: Chemical communications. Volume 59:Issue 21(2023)
• Page Start: 3111
• Page End: 3113
• Publication Date: 2023-02-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc07004a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Sensitive high-resolution multidimensional solid-state NMR method is reported for facile identification of hydrogen-bonded 15 N– 17 O pairs in peptides. Abstract : High sensitivity and resolution solid-state NMR methods are reported, that straightforwardly select hydrogen-bonded 15 N– 17 O pairs from amongst all other nitrogen and oxygen sites in peptides, to aid protein secondary and tertiary structure determination. Significantly improved sensitivity is obtained with indirect 1 H detection under fast MAS and stronger relayed dipole couplings.