Stereoselective synthesis of E-monofluorovinyl pyridin-4-yl ethers by the reaction of gem-difluoroalkenes with pyridin-4-yl boronic acid and oxygen. (24th March 2023)

• Record Type: Journal Article
• Authors: Zhang, Xuxue; Sun, Yuzhen; Yan, Xinsheng; Jin, Chen; Deng, Yupian; Cao, Song
• Is Part Of: Tetrahedron letters. Volume 118(2023)
• Publication Date: 2023-03-24
• Subjects: Gem-difluoroalkenes -- Pyridin-4-yl boronic acid -- Stereoselectivity -- E-monofluorovinyl pyridin-4-yl ethers; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2023.154390
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Monofluorovinyl esters are important structural motifs. The functionalized monofluoroalkenes are valuable synthetic intermediates. gem-Difluoroalkenes reacted with pyridin-4-yl boronic acid and oxygen. Stereoselective synthesis of E-monofluorovinyl pyridin-4-yl ethers. Abstract: A convenient and efficient method for the highly stereoselective synthesis of E -monofluorovinyl pyridin-4-yl ethers by the reaction of gem -difluoroalkenes with pyridin-4-yl boronic acid and oxygen with the assistance of K3 PO4 is described.