Self‐Assembly Protein Nanogels for Safer Cancer Immunotherapy. Issue 12 (21st April 2016)

• Record Type: Journal Article
• Authors: Purwada, Alberto; Tian, Ye F.; Huang, Weishan; Rohrbach, Kathleen M.; Deol, Simrita; August, Avery; Singh, Ankur
• Is Part Of: Advanced healthcare materials. Volume 5:Issue 12(2016)
• Page Start: 1413
• Page End: 1419
• Publication Date: 2016-04-21
• Subjects: antigen -- immunomodulation -- immunotherapy -- nanogels -- T cell; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201501062
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Soluble antigen‐based cancer vaccines have poor retention in tissues along with suboptimal antigen processing by dendritic cells. Multiple booster doses are often needed, leading to dose‐limiting systemic toxicity . A versatile, immunomodulatory, self‐assembly protein nanogel vaccine is reported that induces robust immune cell response at lower antigen doses than soluble antigens, an important step towards biomaterials‐based safer immunotherapy approaches.