Early Parkinson's disease symptoms in α-synuclein transgenic monkeys. (30th December 2014)
- Record Type:
- Journal Article
- Title:
- Early Parkinson's disease symptoms in α-synuclein transgenic monkeys. (30th December 2014)
- Main Title:
- Early Parkinson's disease symptoms in α-synuclein transgenic monkeys
- Authors:
- Niu, Yuyu
Guo, Xiangyu
Chen, Yongchang
Wang, Chuan-En
Gao, Jinquan
Yang, Weili
Kang, Yu
Si, Wei
Wang, Hong
Yang, Shang-Hsun
Li, Shihua
Ji, Weizhi
Li, Xiao-Jiang - Abstract:
- Abstract: Parkinson's disease (PD) is an age-dependent neurodegenerative disease that can be caused by genetic mutations in α-synuclein (α-syn) or duplication of wild-type α-syn; PD is characterized by the deposition of α-syn aggregates, indicating a gain of toxicity from accumulation of α-syn. Although the major neuropathologic feature of PD is the degeneration of dopaminergic (DA) neurons in the substantia nigra, non-motor symptoms including anxiety, cognitive defect and sleep disorder precede the onset of motor impairment, and many clinical symptoms of PD are not caused by degeneration of DA neurons. Non-human primate models of PD are important for revealing the early pathology in PD and identifying effective treatments. We established transgenic PD rhesus monkeys that express mutant α-syn (A53T). Six transgenic A53T monkeys were produced via lentiviral vector expressing A53T in fertilized monkey eggs and subsequent embryo transfer to surrogates. Transgenic A53T is expressed in the monkey brain and causes age-dependent non-motor symptoms, including cognitive defects and anxiety phenotype, without detectable sleeping disorders. The transgenic α-syn monkeys demonstrate the specific early symptoms caused by mutant α-syn and provide insight into treatment of early PD.
- Is Part Of:
- Human molecular genetics. Volume 24:Number 8(2015:Apr. 15)
- Journal:
- Human molecular genetics
- Issue:
- Volume 24:Number 8(2015:Apr. 15)
- Issue Display:
- Volume 24, Issue 8 (2015)
- Year:
- 2015
- Volume:
- 24
- Issue:
- 8
- Issue Sort Value:
- 2015-0024-0008-0000
- Page Start:
- 2308
- Page End:
- 2317
- Publication Date:
- 2014-12-30
- Subjects:
- Human molecular genetics -- Periodicals
Human chromosome abnormalities -- Periodicals
572.8 - Journal URLs:
- http://hmg.oxfordjournals.org/ ↗
http://ukcatalogue.oup.com/ ↗ - DOI:
- 10.1093/hmg/ddu748 ↗
- Languages:
- English
- ISSNs:
- 0964-6906
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4336.198000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 26131.xml