Fabrication of a positional brain shift phantom through the utilization of the frozen intermediate hydrogel state. (April 2023)

• Record Type: Journal Article
• Authors: Potts, Matthew R.; Bennion, Nicholas J.; Zappalá, Stefano; Marshall, David; Harrison, Rob; Evans, Sam L.
• Is Part Of: Journal of the mechanical behavior of biomedical materials. Volume 140(2023)
• Publication Date: 2023-04
• Subjects: Brain phantom -- Hydrogel -- Brain shift -- Gravity -- Head position; Biomedical materials -- Periodicals; Biomedical materials -- Mechanical properties -- Periodicals; Biomedical materials; Biomedical materials -- Mechanical properties; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.jmbbm.2023.105704
• Languages: English
• ISSNs: 1751-6161

Abstract

Abstract: Synthetic models (phantoms) of the brain-skull system are useful tools for the study of surgical events that are otherwise difficult to study directly in humans. To date, very few studies can be found which replicate the full anatomical brain-skull system. Such models are required to study the more global mechanical events that can occur in neurosurgery, such as positional brain shift. Presented in this work is a novel workflow for the fabrication of a biofidelic brain-skull phantom which features a full hydrogel brain with fluid-filled ventricle/fissure spaces, elastomer dural septa and fluid-filled skull. Central to this workflow is the utilization of the frozen intermediate curing state of an established brain tissue surrogate, which allows for a novel moulding and skull installation approach that permits a much fuller recreation of the anatomy. The mechanical realism of the phantom was validated through indentation testing of the phantom's brain and simulation of the supine to prone brain shift event, while the geometric realism was validated through magnetic resonance imaging. The developed phantom captured a novel measurement of the supine to prone brain shift event with a magnitude that accurately reproduces that seen in the literature. Graphical abstract: Image 1 Highlights: Development of a deformable brain-skull phantom for the study of positional brain shift. Development of a workflow for the fabrication of geometrically complex brain phantoms in a mechanically realistic material. Mechanical testing and optimisation of hydrogel for use in a positional brain shift phantom. Measurement of the supine to prone positional brain shift event with the developed phantom through CT imaging.