Co-presence of Epstein–Barr virus and high-risk human papillomaviruses in Syrian colorectal cancer samples. Issue 10 (2nd October 2020)

• Record Type: Journal Article
• Authors: Malki, Mohammed I.; Gupta, Ishita; Fernandes, Queenie; Aboulkassim, Tahar; Yasmeen, Amber; Vranic, Semir; Al Moustafa, Ala-Eddin; Al-Thawadi, Hamda A.
• Is Part Of: Human vaccines & immunotherapeutics. Volume 16:Issue 10(2020)
• Page Start: 2403
• Page End: 2407
• Publication Date: 2020-10-02
• Subjects: EBV -- high-risk HPV -- colorectal cancer -- Syrian population -- cancer phenotype; Vaccines -- Periodicals; 615.372
• DOI: 10.1080/21645515.2020.1726680
• Languages: English
• ISSNs: 2164-5515

Abstract

ABSTRACT: We recently performed two studies exploring the presence of Epstein–Barr virus (EBV) and high-risk human papillomaviruses (HPVs) types 16, 18, 31, 33 and 35 in human colorectal cancers from the Syrian population. Herein, we report that EBV and high-risk HPVs are co-present in colorectal cancers from Syria. We reveal that 17 (~17%) of 102 cancer samples are positive for both EBV and high-risk HPVs and their co-presence is associated with high/intermediate grade invasive carcinomas. These data suggest that EBV and high-risk HPVs are co-present in human colorectal cancers where they might cooperate on the initiation and/or progression of these cancers. Thus, we believe that future studies are necessary to confirm the co-presence of these oncoviruses and their cooperative role in human colorectal carcinogenesis.