Colorectal cancer risk in East Asian patients with Helicobacter pylori infection: A systematic review and meta-analysis. Issue 10 (10th March 2023)

• Record Type: Journal Article
• Authors: Ma, Lijuan; Guo, Wentao; Zeng, Zhihui; Yang, Fei; Tang, Shufang; Ling, Yarui
• Is Part Of: Medicine. Volume 102:Issue 10(2023)
• Page Start: e33177
• Publication Date: 2023-03-10
• Subjects: colorectal cancer -- East Asian -- Helicobacter pylori -- meta-analysis -- risk; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000033177
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Background: The aim of this systematic review and meta-analysis was to assess the relationship between H pylori infection and colorectal cancer risk in East Asian patients. Methods: Two researchers independently searched for relevant studies in the PubMed, Cochrane, and Embase databases from inception up to April 2022. A meta-analysis was then performed to calculate pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) using a random effects model. Results: Nine studies involving 6355 patients were included. Overall, we observed that H pylori infection was associated with an increased risk of colorectal cancer in East Asian patients (OR = 1.48, 95% CI: 1.10–1.99, I 2 = 70%), although significant heterogeneity was identified among studies. Subgroup analysis revealed that H pylori infection was associated with an increased risk of colorectal cancer in China (OR = 1.58, 95% CI 1.05–2.37, I 2 = 81%) but not in Japan and Korea (OR = 1.26, 95% CI 0.93–1.70, I 2 = 0%). Conclusion: This meta-analysis identified a positive association between H pylori infection and colorectal cancer risk in East Asian patients, especially in China.