A Case of a Beta-Catenin-Activated Hepatic Adenoma in a Male Patient With Familial Adenomatous Polyposis. Issue 3 (16th March 2023)

• Record Type: Journal Article
• Authors: Kusnik, Alexander; Li, Shifan; Graziano, Elliot; Katerji, Roula; Ramaraju, Gopal
• Is Part Of: ACG Case Reports Journal. Volume 10:Issue 3(2023)
• Page Start: e01012
• Publication Date: 2023-03-16
• Subjects: hepatic adenoma -- familial adenomatous polyposis -- beta-catenin
• DOI: 10.14309/crj.0000000000001012
• Languages: English
• ISSNs: 2326-3253

Abstract

ABSTRACT: Hepatocellular adenoma is a benign liver tumor often diagnosed incidentally in women of reproductive age who are taking oral contraceptives. In this study, we present a unique case of an 18-year-old man with known familial adenomatous polyposis who presented with sepsis in the setting of a recent total proctocolectomy and was incidentally found to have multiple large hepatic lesions. A biopsy of a liver lesion confirmed the diagnosis of a beta-catenin-activated hepatic adenoma. To the best of our knowledge, this is the first known case of beta-catenin-activated hepatic adenoma in a patient with a known familial adenomatous polyposis mutation. Beta-catenin is one of the many subtypes of hepatocellular adenomas, which carries a high risk of malignant transformation.