Copper Catalyzed Direct Synthesis of Unsymmetrically Substituted Oxalamides From Bromodifluoroacetamide and Tertiary Amines. Issue 4 (17th March 2021)

• Record Type: Journal Article
• Authors: Chen, Hongtai; Wang, Lianxin; Liu, Yujie; Guo, Minjie; Zhao, Wentao; Tang, Xiangyang; Wang, Guangwei
• Is Part Of: Asian journal of organic chemistry. Volume 10:Issue 4(2021)
• Page Start: 780
• Page End: 783
• Publication Date: 2021-03-17
• Subjects: unsymmetrical oxalamides -- tertiary amines -- bromodifluoroacetamides -- oxidative C-N bond cleavage -- defluorination; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202100044
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: An efficient method for the synthesis of unsymmetrical oxalamides has been developed using bromodifluoroacetamide and tertiary amines under mild reaction conditions. This protocol provides a convenient and straightforward strategy for the rapid construction of various unsymmetrically N ‐substituted oxalamides moieties in a single step. Abstract : A novel protocol for the direct synthesis of unsymmetrical oxalamides from tertiary amines and bromodifluoroacetamides was developed.