Abundant tannic acid modified gelatin/sodium alginate biocomposite hydrogels with high toughness, antifreezing, antioxidant and antibacterial properties. (1st June 2023)

• Record Type: Journal Article
• Authors: Zhang, Xiumei; Liu, Kejun; Qin, Miao; Lan, Weiwei; Wang, Longfei; Liang, Ziwei; Li, Xiaochun; Wei, Yan; Hu, Yinchun; Zhao, Liqin; Lian, Xiaojie; Huang, Di
• Is Part Of: Carbohydrate polymers. Volume 309(2023)
• Publication Date: 2023-06-01
• Subjects: Tannic acid -- Gelatin/sodium alginate hydrogel -- High toughness -- Antioxidant -- Antibacterial; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2023.120702
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: The acidity of high tannic acid (TA) content solution can destroy the structure of protein, such as gelatin (G). This causes a big challenge to introduce abundant TA into the G-based hydrogels. Here, the G-based hydrogel system with abundant TA as hydrogen bonds provider was constructed by a "protective film" strategy. The protective film around the composite hydrogel was first formed by the chelation of sodium alginate (SA) and Ca 2+ . Subsequently, abundant TA and Ca 2+ were successively introduced into the hydrogel system by immersing method. This strategy effectively protected the structure of the designed hydrogel. After treatment with 0.3 w/v TA and 0.06 w/v Ca 2+ solutions, the tensile modulus, elongation at break and toughness of G/SA hydrogel increased about 4-, 2-, and 6-fold, respectively. Besides, G/SA-TA/Ca 2+ hydrogels exhibited good water retention, anti-freezing, antioxidant, antibacterial properties and low hemolysis ratio. Cell experiments showed that G/SA-TA/Ca 2+ hydrogels possessed good biocompatibility and could promote cell migration. Therefore, G/SA-TA/Ca 2+ hydrogels are expected to be used in the field of biomedical engineering. The strategy proposed in this work also provides a new idea for improving the properties of other protein-based hydrogels. Graphical abstract: Unlabelled Image