Strong chemiluminescence intensities of bis-acridinium esters under neutral and alkaline conditions. (May 2023)

• Record Type: Journal Article
• Authors: Nakazono, Manabu; Hamase, Kenji
• Is Part Of: Dyes and pigments. Volume 213(2023)
• Publication Date: 2023-05
• Subjects: Chemiluminescence -- Bis-acridinium ester -- Hydrogen peroxide -- Catalase activity; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2023.111175
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: Four novel bis-acridinium esters were synthesized using common methods, and their chemiluminescence properties were investigated at pH 7−10. In the chemiluminescence of bis-acridinium esters, the introduction of fluorine at the 2-position of the phenyl ring and methyl groups at the 2, 7-positions of the acridine ring changed greatly the chemiluminescence intensities. Pentane-1, 5-diyl bis(2-fluoro-4-(2, 7, 10-trimethylacridinium-9-carbonyloxy)benzoate) bis(trifluoromethanesulfonate) showed strong chemiluminescence and long-lasting chemiluminescence under both neutral and alkaline conditions. Pentane-1, 5-diyl bis(2-fluoro-4-(10-methylacridinium-9-carbonyloxy)benzoate) bis(trifluoromethanesulfonate) was applied for highly sensitive chemiluminescence determination of hydrogen peroxide and catalase activity. The linear calibration ranges of hydrogen peroxide and catalase activity were 5–1000 μM (R = 0.999) and 0.05−1 U/mL (R = 0.998), respectively. Graphical abstract: Image 1 Highlights: Development of novel bis-acridinium ester derivatives. Strong chemiluminescence under both neutral and alkaline conditions. Simple and highly sensitive chemiluminescence method of hydrogen peroxide and catalase activity.