Electroencephalography complexity in resting and task states in adults with attention-deficit/hyperactivity disorder. Issue 2 (7th March 2022)

• Record Type: Journal Article
• Authors: Gu, Chao; Liu, Zhong-Xu; Woltering, Steven
• Is Part Of: Brain communications. Volume 4:Issue 2(2022)
• Publication Date: 2022-03-07
• Subjects: EEG -- multiscale entropy -- ADHD -- resting state -- task state; 616
• DOI: 10.1093/braincomms/fcac054
• Languages: English
• ISSNs: 2632-1297

Abstract

Abstract: Analysing EEG complexity could provide insight into neural connectivity underlying attention-deficit/hyperactivity disorder symptoms. EEG complexity was calculated through multiscale entropy and compared between adults with attention-deficit/hyperactivity disorder and their peers during resting and go/nogo task states. Multiscale entropy change from the resting state to the task state was also examined as an index of the brain's ability to change from a resting to an active state. Thirty unmedicated adults with attention-deficit/hyperactivity disorder were compared with 30 match-paired healthy peers on the multiscale entropy in the resting and task states as well as their multiscale entropy change. Results showed differences in multiscale entropy between individuals with attention-deficit/hyperactivity disorder and their peers during the resting state as well as the task state. The multiscale entropy measured from the comparison group was larger than that from the attention-deficit/hyperactivity disorder group in the resting state, whereas the reverse pattern was found during the task state. Our most robust finding showed that the multiscale entropy change from individuals with attention-deficit/hyperactivity disorder was smaller than that from their peers, specifically at frontal sites. Interestingly, individuals without attention-deficit/hyperactivity disorder performed better with decreasing multiscale entropy changes, demonstrating higher accuracy, faster reaction time and less variability in their reaction times. These data suggest that multiscale entropy could not only provide insight into neural connectivity differences between adults with attention-deficit/hyperactivity disorder and their peers but also into their behavioural performance. Abstract : Gu et al . found that the brains of individuals with attention-deficit/hyperactivity disorder are less variable when comparing passive to active mental states than the brains of their peers. Findings increase our understanding of different mental states and flexibly shift between them in attention-deficit/hyperactivity disorder. Graphical Abstract: Graphical Abstract