Electrophysiological-mechanical coupling in the neuronal membrane and its role in ultrasound neuromodulation and general anaesthesia. (1st October 2019)

• Record Type: Journal Article
• Authors: Jerusalem, Antoine; Al-Rekabi, Zeinab; Chen, Haoyu; Ercole, Ari; Malboubi, Majid; Tamayo-Elizalde, Miren; Verhagen, Lennart; Contera, Sonia
• Is Part Of: Acta biomaterialia. Volume 97(2019)
• Page Start: 116
• Page End: 140
• Publication Date: 2019-10-01
• Subjects: Neuroscience -- Cell multiphysics -- Neuromodulation -- Transcranial ultrasound stimulation -- Anaesthetics; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1016/j.actbio.2019.07.041
• Languages: English
• ISSNs: 1742-7061

Abstract

Graphical abstract: Abstract: The current understanding of the role of the cell membrane is in a state of flux. Recent experiments show that conventional models, considering only electrophysiological properties of a passive membrane, are incomplete. The neuronal membrane is an active structure with mechanical properties that modulate electrophysiology. Protein transport, lipid bilayer phase, membrane pressure and stiffness can all influence membrane capacitance and action potential propagation. A mounting body of evidence indicates that neuronal mechanics and electrophysiology are coupled, and together shape the membrane potential in tight coordination with other physical properties. In this review, we summarise recent updates concerning electrophysiological-mechanical coupling in neuronal function. In particular, we aim at making the link with two relevant yet often disconnected fields with strong clinical potential: the use of mechanical vibrations—ultrasound—to alter the electrophysiogical state of neurons, e.g., in neuromodulation, and the theories attempting to explain the action of general anaesthetics. Statement of Significance: General anaesthetics revolutionised medical practice; now an apparently unrelated technique, ultrasound neuromodulation—aimed at controlling neuronal activity by means of ultrasound—is poised to achieve a similar level of impact. While both technologies are known to alter the electrophysiology of neurons, the way they achieve it is still largely unknown. In this review, we argue that in order to explain their mechanisms/effects, the neuronal membrane must be considered as a coupled mechano-electrophysiological system that consists of multiple physical processes occurring concurrently and collaboratively, as opposed to sequentially and independently. In this framework the behaviour of the cell membrane is not the result of stereotypical mechanisms in isolation but instead emerges from the integrative behaviour of a complexly coupled multiphysics system.