Transition metal-free electrochemical fluorotrifluoromethylation of Styrenes. Issue 5 (1st February 2023)

• Record Type: Journal Article
• Authors: Lu, Yi; Liu, Zhirui; Liu, Chao; Wu, Yunpeng; Li, Lu; Liu, Siyuan; Wang, Hong; Gao, Wei; Liu, Zhenxian; Chen, Jianbin
• Is Part Of: Organic chemistry frontiers. Volume 10:Issue 5(2023)
• Page Start: 1283
• Page End: 1288
• Publication Date: 2023-02-01
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo01947g
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : An environmentally friendly electrochemical fluorotrifluoromethylation of styrenes is developed using CF3 SO2 Na and Et3 N·3HF as the F-containing donor reagents. This synthetic strategy features step economy and sustainability. Abstract : An environmentally friendly electrochemical fluorotrifluoromethylation of styrenes was developed via the tandem processes of electro-oxidation and radical and nucleophilic addition. By using commercial CF3 SO2 Na and Et3 N·3HF as the CF3 and F sources, respectively, a series of potentially bio-active multi-site F-containing compounds were obtained in moderate to good yields. This fluorotrifluoromethylation strategy is catalyst- and oxidant-free, and demonstrates mild conditions and high step economy features. In addition, several analytical methods, including cyclic voltammetry and control experiments, were conducted to investigate a reasonable reaction mechanism.