Autophagy and autophagy‐related molecules in neurodegenerative diseases. Issue 1 (22nd June 2022)

• Record Type: Journal Article
• Authors: Dou, Changsong; Zhang, Yu; Zhang, Ling; Qin, Chuan
• Is Part Of: Animal models and experimental medicine. Volume 6:Issue 1(2023)
• Page Start: 10
• Page End: 17
• Publication Date: 2022-06-22
• Subjects: autophagy -- mitophagy -- neurodegenerative -- TFEB; Laboratory animals -- Periodicals; Diseases -- Animal models -- Periodicals; Animal models in research -- Periodicals; Veterinary medicine -- Periodicals; Laboratory Animal Science; Disease Models, Animal; Animals, Laboratory; Animal Welfare; Veterinary Medicine; Animal models in research; Diseases -- Animal models; Laboratory animals; Veterinary medicine; Periodicals; Fulltext; Internet Resources; Periodicals; Periodicals; 616.0273
• DOI: 10.1002/ame2.12229
• Languages: English
• ISSNs: 2576-2095

Abstract

Abstract: Autophagy is one of the degradation pathways to remove proteins or damaged organelles in cells that plays an important role in neuroprotection. Different stages of autophagy are regulated by autophagy‐related genes, and many molecules such as transcription factor EB (TFEB) are involved. The complete autophagy process plays an important role in maintaining the dynamic balance of autophagy and is crucial to the homeostasis of intracellular substance and energy metabolism. Autophagy balance is disrupted in neurodegenerative diseases, accounting for a variety of degeneration disorders. These impairments can be alleviated or treated by the regulation of autophagy through molecules such as TFEB. Abstract : In this manuscript, we elucidate the possible effect of autophagy and autophagy‐related molecules in neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. Also, these molecules have huge implications for the treatment of neurodegenerative diseases.