Amplification of Lipid Peroxidation by Regulating Cell Membrane Unsaturation To Enhance Chemodynamic Therapy. Issue 12 (14th February 2023)

• Record Type: Journal Article
• Authors: Zhu, Yang; Gong, Peng; Wang, Jun; Cheng, Junjie; Wang, Wenyu; Cai, Huilan; Ao, Rujiang; Huang, Hongwei; Yu, Meili; Lin, Lisen; Chen, Xiaoyuan
• Is Part Of: Angewandte Chemie international edition. Volume 62:Issue 12(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-02-14
• Subjects: Antitumor Agents -- Chemodynamic Therapy -- Lipid Peroxidation -- Polyunsaturated Fatty Acids -- Single-Atom Catalysts; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202218407
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Lipid peroxidation (LPO) is one of the most damaging processes in chemodynamic therapy (CDT). Although it is well known that polyunsaturated fatty acids (PUFAs) are much more susceptible than saturated or monounsaturated ones to LPO, there is no study exploring the effect of cell membrane unsaturation degree on CDT. Here, we report a self‐reinforcing CDT agent (denoted as OA@Fe‐SAC@EM NPs), consisting of oleanolic acid (OA)‐loaded iron single‐atom catalyst (Fe‐SAC)‐embedded hollow carbon nanospheres encapsulated by an erythrocyte membrane (EM), which promotes LPO to improve chemodynamic efficacy via modulating the degree of membrane unsaturation. Upon uptake of OA@Fe‐SAC@EM NPs by cancer cells, Fe‐SAC‐catalyzed conversion of endogenous hydrogen peroxide into hydroxyl radicals, in addition to initiating the chemodynamic therapeutic process, causes the dissociation of the EM shell and the ensuing release of OA that can enrich cellular membranes with PUFAs, enabling LPO amplification‐enhanced CDT. Abstract : A self‐reinforcing chemodynamic therapy (CDT) agent was prepared by loading oleanolic acid (OA) into hollow carbon‐supported iron single‐atom catalysts (Fe‐SAC) prior to coating with erythrocyte membrane (EM). Fe‐SAC‐catalyzed ⋅OH generation from H2 O2, in addition to initiating CDT, triggers EM destruction to release OA, which can amplify lipid peroxidation by enriching cell membranes with polyunsaturated fatty acids, enabling enhanced CDT efficacy.