Utility of 5‐aminolaevulinic acid fluorescence‐guided endoscopic biopsy for malignant mesothelioma in a cat and dog. Issue 3 (8th December 2022)

• Record Type: Journal Article
• Authors: Osaki, T; Amaha, T; Murahata, Y; Sunden, Y; Iguchi, A; Harada, K; Tsujino, K; Murakami, K; Ishii, T; Takahashi, K; Ishizuka, M; Tanaka, T; Okamoto, Y
• Is Part Of: Australian veterinary journal. Volume 101:Issue 3(2023)
• Page Start: 99
• Page End: 105
• Publication Date: 2022-12-08
• Subjects: cat -- chemotherapy -- dog -- laparoscopy -- thoracoscopy; Veterinary medicine -- Australia -- Periodicals; Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; 636.089
• DOI: 10.1111/avj.13224
• Languages: English
• ISSNs: 0005-0423

Abstract

Abstract : Malignant mesothelioma (MM) is uncommon in cats and dogs and can be challenging to diagnose. Adequate tissue sampling is required for superior diagnostic accuracy. Protoporphyrin IX, a metabolite of 5‐aminolaevulinic acid (5‐ALA), is a photosensitiser for photodynamic diagnosis (PDD). To the best of our knowledge, no study has reported the use of 5‐ALA‐PDD to detect MM in veterinary medicine. The present study describes the use of 5‐ALA‐PDD for MM diagnosis in a cat and dog, as well as the effectiveness of intracavitary chemotherapy. We evaluated the use of PDD with 5‐ALA hydrochloride (5‐ALA‐PDD) in two cases of MM. A 12‐year‐old cat presented with a 1‐month history of respiratory distress, and a 9‐year‐old dog presented with a 3‐month history of mild abdominal distention. We endoscopically biopsied lesions in both the cases using 5‐ALA‐PDD. Histopathological examination revealed mesothelioma, and immunohistochemical staining was positive for calretinin. Both patients were treated with carboplatin. The cat died of respiratory failure. Although, the dog's condition improved 21 days after the first chemotherapeutic drug administration, the dog died on day 684 owing to cardiac‐related issues. 5‐ALA‐PDD is thus, safe and feasible for the diagnosis of MM in veterinary medicine.