Psidium cattleianum fruit extract prevents systemic alterations in an animal model of type 2 diabetes mellitus: comparison with metformin effects. (17th February 2023)

• Record Type: Journal Article
• Authors: Cardoso, Juliane De Souza; Cardoso Teixeira, Fernanda; De Mello, Julia Eisenhardt; Soares De Aguiar, Mayara Sandrielly; Souto Oliveira, Pathise; Torchelsen Saraiva, Juliane; Vizzotto, Marcia; Borelli Grecco, Fabiane; Lencina, Claiton Leoneti; Spanevello, Roselia Maria; Tavares, Rejane Giacomelli; Stefanello, Francieli Moro
• Is Part Of: Biomarkers. Volume 28:Number 2(2023)
• Page Start: 238
• Page End: 248
• Publication Date: 2023-02-17
• Subjects: Diabetes -- animal model -- metformin -- oxidative stress -- phenolic compounds; Biochemical markers -- Periodicals; 610.28
• DOI: 10.1080/1354750X.2022.2163695
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Objective: In this study, we aimed to determine the role of Psidium cattleianum extract (PCE) and compare its effects with those of metformin (Met) in an animal model with type 2 diabetes mellitus (T2DM). Methods: T2DM was induced in rats using a high-fat diet (HFD), followed by a single dose of streptozotocin (STZ). Met and PCE were administered intragastrically once a day throughout the experiment, and their effects on biochemical, inflammatory, oxidative, and histological parameters were evaluated. Results: Met and PCE prevented the increase in serum levels of glucose, total cholesterol (TC), triacylglycerol (TG), very low-density lipoprotein (VLDL) and interleukin-6 (IL-6) induced by T2DM, and restored redox homeostasis in the liver and brain. Met increased the serum levels of anti-inflammatory cytokine and interleukin-10 (IL-10). Furthermore, both treatments restored the liver and pancreas from marked cellular disorganisation, vacuolisation, and necrosis, with PCE being more effective than Met in recovering histological changes. Conclusion: PCE is a promising agent for the prevention of T2DM complications.