Multiplexed and continuous microfluidic sensors using dynamic complex droplets. Issue 10 (21st February 2023) - Barua, Baishali
Abstract : The combination of emissive complex droplets and PDMS microfluidic devices offers a promising framework for real-time, continuous, and multiplexed sensing platform. Abstract : Emissive complex droplets with reconfigurable morphology and dynamic optical properties offer exciting opportunities as chemical sensors due to their stimuli-responsive characteristics. In this work, we demonstrated a real-time optical sensing platform that combines poly(dimethylsiloxane) (PDMS) microfluidics and complex droplets as sensing materials. We utilized a mechanism, called directional emission, to transduce changes in interfacial tension into optical signals. We discuss the fabrication and integration of PDMS microfluidics with complex emulsions to facilitate continuous measurement of fluorescent emission and, ultimately, the interfacial tensions. Furthermore, by varying the interfacial functionalization and fluorescent dye with characteristic wavelength, we generate multiple formulations of droplets and obtain differential responses to stimuli that alter interfacial tensions ( i.e., composition of surfactants, pH). Our results illustrate a proof-of-concept multiplexed and continuous sensing platform with potential applications in miniaturized, on-site environmental monitoring and biosensing.